Although there are currently no active audio podcasts dedicated exclusively to the Apple II, the following retrocomputing shows often feature our favorite computer.
ANTIC: The Atari 8-bit Podcast
Hundreds of interviews of Atari luminaries by Kay Savetz, with the occasional panel featuring Kay, Brad Arnold, and Randy Kindig.
Disclaimer: This index is not intended to be comprehensive. No podcast has paid to be included on this list, nor is inclusion necessarily an endorsement. All podcasts are listed alphabetically.